PPDO滑扣型血管支架制备方法与性能研究

李瑜; 卞平艳; 童景琳

doi:10.13433/j.cnki.1003-8728.2015.1024

PPDO滑扣型血管支架制备方法与性能研究

doi: 10.13433/j.cnki.1003-8728.2015.1024

1.
河南理工大学机械与动力工程学院, 焦作 454000

基金项目:

国家自然科学基金项目(81070134)与河南省高校精密制造技术与工程重点学科开放实验室基金项目(PMTE201305A)资助

详细信息

作者简介:
李瑜(1982-),实验师,硕士,研究方向为生物制造与增材制造,精密超精密制造,liyu@hpu.edu.cn

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- 文章访问数: 243
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- PDF下载量: 11
- 被引次数: 0
出版历程
- 收稿日期: 2013-11-08
- 刊出日期: 2015-10-05

Investigation of Preparations and Characters of PPDO Slide Fastener Type Stents

1.
School of Mechanical and Power Engineering, Henan Polytechnic University, Jiaozuo 454000, China

摘要

摘要: 比较成形工艺对聚对二氧环已酮(PPDO)滑扣式可降解血管支架性能的影响。对微压印和3D打印(3DP)两种聚合物成形工艺进行比较,主要包括其成形表面质量和径向强度两方面。试验结果显示:微压印制备支架内表面Ra0.429、外表面Ra1.24,优于3DP制备支架,而支架内外表面质量的差异化与可控性也更适合血管支架在抑制凝血和置放稳定等临床医学的需要;另外,两种制备方法所制支架的径向强度均高于临床需要的80 kPa的标准,其中微压印比3DP略高4%。原因可能是微压印制备将PPDO材料的成形温度降低在材料粘流态温度范围内,使该高分子材料的热降解大大降低,较好的保留了原材料的力学性能与强度保障时间。
- 聚对二氧环己酮 /
- 血管支架 /
- 微压印 /
- 3D打印 /
- 粘流态
Abstract: Two preparations of the PPDO(Poly p-dioxanone) degradable vascular stents, micro-imprint and 3D Printing was investigated. And each type samples' characters were studied, such as surface quality and radial strength. The results showed that, the surface quality of micro-imprint samples appears a group of average dates, inner surface Ra 0.429 and outside surface Ra 1.24, which is superior to the 3D Printing ones. And the diversity and controllability of the inner and outside surface quality, is more meet the clinical medicine requirement in the sections of inhibiting blood coagulation and steady placement. In addition, the intensity of radial strength of two kinds samples are higher than the clinical requirement(80 kPa), and the micro-imprint one is slightly higher than that of 3D Printing by 4%. This phenomenon was attributed to the forming temperature. In the micro-imprint process, the PPDO was fabricated in the viscous state, which made the thermal degradation of the polymer materials greatly reduced, better retention of mechanical properties and guarantee time of strength.
- 3D Printing /
- blood /
- intravascular stents /
- measurements /
- mechanical properties

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参考文献(16)

[1]	Nef H M, Möllmann H, Weber M, et al. Cobalt-chrome Multi-Link Vision-stent implantation in diabetics and complex lesions:results from the DaVinci-Registry[J]. Clin Res Cardiol, 2009,98(11):731-737
[2]	杨科柯,王玉忠.一种新型可循环利用的生物降解高分子材料PPDO[J]. 中国材料进展,2011,30(8):25-34 Yang K K, Wang Y Z. A recyclable and biodegradable polymer:Poly(p-Dioxanone)[J]. Materials China, 2011,30(8):25-34(in Chinese)
[3]	Heckele M, Schomburg W K. Review on micro molding of thermoplastic polymers[J]. Journal of Micromechanics and Microengineering, 2004,14(3):R1-R14
[4]	王一涵,窦红静,孙康,等.可降解血管支架的动态力学性能[J]. 上海交通大学学报,2010,44(11):1605-1609 Wang Y H, Dou H J, Sun K, et al. Dynamic mechanical properties of biodegradable stents[J]. Journal of Shanghai Jiaotong University, 2010,44(11):1605-1609(in Chinese)
[5]	Feng Q M, Jiang W B, Sun K, et al. Mechanical properties and in vivo performance of a novel sliding-lock bioabsorbable poly-p-dioxanone stent[J]. J Mater Sci:Mater Med, 2011,22(10):2319-2327
[6]	Zhao L J, Sun K, Feng Q M, et al. Evaluation of hemocompatibility of a new biopolymer material for bioabsorbable stents used for children with vascular stenosis in vitro[J]. J Clin Pediatr, 2010,28(9):801-806
[7]	孙锟,孙康,冯其茂,等.新型滑扣生物可吸收支架. ZL201010111299[P]. 2011 Sun K, Sun K, Feng Q M, et al. A novel bioabsorbable sliding-lock stents. China ZL201010111299[P]. 2011(in Chinese)
[8]	Schmidt W, Andresen R, Behrens P, et al. Characteristic mechanical properties of balloon-expandable peripheral stent systems[J]. Rofo, 2002,174(11):1430-1437
[9]	Nishidaa H, Yamashitab M, Endoc T. Analysis of initial process in pyrolysis of poly(p-dioxanone)[J]. Polym Degrad Stab, 2002,78(1):129-135
[10]	Bezwada R S, Jamiokowski D D, Cooper K. Handbook of biodegradable polymers[M]. Singapore:Harwood Academic Publishers, 1997
[11]	Liu C D, Andjelic S, Zhou J, et al. Thermal stability and melt rheology of poly(p-dioxanone)[J]. J Mater Sci:Mater Med, 2008,19(12):3481-3487
[12]	Schmidt W, Andresen R, Behrens P. Characteristic mechanical properties of balloon-expandable peripheral stent systems[J]. Rofo, 2002,174(11):1430-1437
[13]	俞耀庭,张兴栋.生物医用材料[M]. 天津:天津大学出版社,2000:224-225 Yu Y T, Zhang X D. Bio-medical materials[M]. Tianjin:Tianjin University Press, 2000:224-225(in Chinese)
[14]	刘强,程晓农,徐红星,等.316L不锈钢和NiTi合金血管支架的血液相容性[J]. 中国组织工程研究与临床康复,2008,12(4):735-738 Liu Q, Cheng X N, Xu H X, et al. Blood compatibility of 316L stainless steel and NiTi alloy vascular stent[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2008,12(4):735-738(in Chinese)
[15]	Park C H, Kim T H, Lee D H, et al. Magnetic polishing of titanium-nickel alloy stents:surface characterization and catheter deployment test[J]. Metallurgical and Materials Transactions A, 2012,43(9):3006-3010
[16]	Lu J, Yao C, Yang L, et al. Decreased Platelet adhesion and enhanced endothelial cell functions on nano and submicron-rough titanium stents[J]. Tissue Engineering Part A, 2012,18(13-14):1389-1398