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论文:2022,Vol:40,Issue(1):222-228 |
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引用本文： |
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赵亚梅, 刘星悦, 霍梦丹, 李泽城, 杨靖. pH/盐双敏性聚醚基咪唑类离子液体凝胶的制备、性质及药物控释机制研究[J]. 西北工业大学学报 |
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ZHAO Yamei, LIU Xingyue, HUO Mengdan, LI Zecheng, YANG Jing. Preparation, properties and drug controlled release mechanism of pH/salt dual-sensitive poly(ether-based imidazoles ionic liquid) gel[J]. Northwestern polytechnical university |
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| pH/盐双敏性聚醚基咪唑类离子液体凝胶的制备、性质及药物控释机制研究 |
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| 赵亚梅1, 刘星悦2, 霍梦丹1, 李泽城1, 杨靖3 |
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1. 西安工程大学 环境与化学工程学院, 陕西 西安 710600;
2. 陕西延长石油(集团)有限责任公司研究院, 陕西 西安 710061;
3. 西安工程大学 城市规划与工程学院, 陕西 西安 710600 |
| 摘要: |
| 以N-乙烯基咪唑为反应物，在咪唑环上引入不同醚基侧链，设计合成了3种pH/盐双敏性聚醚基咪唑类离子液体凝胶（P[CnOC2vim]Cl，n=1，2，3）。用红外光谱、扫描电镜表征了其结构特征，测试了不同条件下凝胶的溶胀性能，并研究了凝胶对药物环丙沙星（CIP）、黄连素（Ber）的缓释效果。结果表明，P[CnOC2vim]Cl （n=1，2，3）凝胶具有明显的pH和盐敏感性，pH升高，溶胀率先增大后减小，在pH为7.4时达到最大；NaCl浓度越高，溶胀率越小。短醚基链P[COC2vim]Cl凝胶在pH=7.4模拟肠液环境中CIP、Ber释放率最高，释放行为均符合一级动力学方程。随着醚基侧链的微增长，P[CnOC2vim]Cl （n=2，3）凝胶对CIP、Ber累积释放率降低，释放行为均符合Higuchi动力学方程。该类凝胶在作为肠道抗菌类药物的pH/盐双敏性控释载体方面有一定潜力。 |
| 关键词:
聚离子液体
刺激响应性凝胶
药物可控释放
生物相容性
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| Preparation, properties and drug controlled release mechanism of pH/salt dual-sensitive poly(ether-based imidazoles ionic liquid) gel |
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| ZHAO Yamei1, LIU Xingyue2, HUO Mengdan1, LI Zecheng1, YANG Jing3 |
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1. School of Environment and Chemical Engineering, Xi'an Polytechnic University, Xi'an 710600, China;
2. Research Institute of Shaanxi Yanchang Petroleum (Group) Co., Ltd., Xi'an 710061, China;
3. School of Urban Planning and Engineering, Xi'an Polytechnic University, Xi'an 710600, China |
| Abstract: |
| Using N-vinylimidazole as the reactant and introducing different ether-based side chains pH/salt dual-sensitive poly(imidazole ionic liquid) gel (P[CnOC2vim]Cl,n=1,2,3) was designed and synthesized. The structure characteristic of the gel was determined by IR spectra and SEM. The swelling ratio of gel under different conditions was investigated, including releasing property for ciprofloxacin (CIP) and berberine (Ber). The results showed that P[CnOC2vim]Cl(n=1,2,3) gel exhibits typical pH-sensitivity and salt-sensitivity. Its swelling ratio increased first and then decreased, and reached the maximum when the value of pH was 7.4; the swelling rate is smaller under the higher concentration of the NaCl. Furthermore, P[COC2vim]Cl gel with the short ether chain has the highest release rate of CIP and Ber at pH=7.4, the release behavior is in accord with the first-order kinetic equation. With the increase of the side chain of ether group, the cumulative release rate of P[CnOC2vim]Cl(n=2,3) gel to CIP and Ber decreased obviously, and the behavior comforts to Higuchi kinetic equation. The results suggest that P[CnOC2vim]Cl(n=1,2,3) gel is the pH/salt dual-sensitive potential carrier for controlled drug release. |
| Key words:
poly(ionic liquid)
stimuli-responsive gel
controlled drug release
biocompatibility
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| 收稿日期: 2021-06-09
修回日期:
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| DOI: 10.1051/jnwpu/20224010222 |
| 基金项目: 陕西省教育厅专项科研计划项目（18JK0340）、西安市科技计划项目（2020KJRC0025）与大学生创新创业训练计划（S202010709076）资助 |
| 通讯作者:
Email： |
| 作者简介: 赵亚梅(1974—),女,西安工程大学副教授,主要从事新型离子液体研究。e-mail:zhaoyameihp@126.com
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参考文献: |
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[1] YAROSLAVOV A A, SYBACHIN A V. Multifunctional carriers for controlled drug delivery[J]. Pure and Applied Chemistry, 2020, 92(6):919-939
[2] BAZBAN-SHOTORBANI S, HASANI-SADRABADI M M, KARKHANEH A, et al. Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications[J]. Journal of Controlled Release, 2017, 253:46-63
[3] CINAY G E, ERKOC P, ALIPOUR M, et al. Nanogel-integrated pH responsive composite hydrogels for controlled drug delivery[J]. ACS Biomaterials Science & Engineering, 2017, 3(3):370-380
[4] ZHANG K H, FENG X L, YE C N, et al. Hydrogels with a memory:dual-responsive, organometallic poly(ionic liquid)s with hysteretic volume-phase transition[J]. Journal of the American Chemical Society, 2017, 139:10029-10035
[5] LE X X, LU W, XIAO H, et al. Fe3+-, pH-, thermoresponsive supramolecular hydrogel with multishape memory effect[J]. ACS Applied Materials & Interfaces, 2017, 9(10):9038-9044
[6] RUWIZHI N, ADERIGBE B A. The Efficacy of cholesterol-based carriers in drug delivery[J]. Molecules, 2020, 25(18):E4330
[7] DAS D, GHOSH P, GHOSH A, et al. Stimulus-responsive, biodegradable, biocompatible, covalently cross-linked hydrogel based on dextrin and poly(N-isopropylacrylamide) for in vitro/in vivo controlled drug release[J]. ACS Applied Materials & Interfaces, 2015, 7(26):14338-14351
[8] 赵亚梅, 刘星悦, 李泽城, 等. pH/盐双敏感型聚离子液体凝胶的制备及对环丙沙星的控制释放[J]. 功能材料, 2021, 52(5):5006-5011 ZHAO Yamei, LIU Xingyue, LI Zecheng, et al. Preparation of pH/salt dual-sensitive polyionic liquid gels and controlled release of ciprofloxacin[J]. Functional Materials, 2021, 52(5):5006-5011(in Chinese)
[9] 周春林. 功能基团对高分子链内及链间相互作用的影响[J]. 复旦学报, 1994, 33(2):165-172 ZHOU Chunlin. The effect of functional groups on the intra-chain and inter-chain interactions of polymers[J]. Journal of Fudan University, 1994, 33(2):165-172(in Chinese)
[10] CHEN H, XU X Z, GONG S D, et al. A comparison of ether-and alkyl-imidazolium-based ionic liquids diluted with CH3CN:a combined FTIR and DFT study[J]. Journal of Molecular Liquids, 2020, 313(9):113542
[11] 邸阳. 醚基阳离子功能化离子液体热力学性质及分子间相互作用的研究[D]. 锦州:渤海大学, 2020 DI Yang. Study on the thermodynamic properties and intermolecular interactions of ether-based cation-functionalized ionic liquids[D]. Jinzhou:Bohai University, 2020(in Chinese)
[12] RAJ J J, MAGARET S, PRANESH M, et al. Dual functionalized imidazolium ionic liquids as a green solvent for extractive desulfurization of fuel oil:toxicology and mechanistic studies[J]. Journal of Cleaner Production, 2019, 213:989-998
[13] 毕玉水. 时间控制/pH依赖型盐酸黄连素结肠给药系统的控释性能[J]. 材料导报, 2018, 32(12):1973-1977 BI Yushui. Controlled release performance of time-controlled/pH-dependent berberine hydrochloride colonic delivery system[J]. Materials Review, 2018, 32(12):1973-1977(in Chinese)
[14] 李润萍. 喘平缓释制剂体外释药机制的研究[D]. 广州:广东药学院, 2012 LI Runping. Study on the in vitro release mechanism of chuanping sustained-release preparations[D]. Guangzhou:Guangdong College of Pharmacy, 2012(in Chinese) |
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