论文:2013,Vol:31,Issue(5):779-784
引用本文:
汪焰恩, 王月波, 杨明明, 潘飞龙, 李欣培, 魏生民. 基于知识库的骨支架可控分形设计[J]. 西北工业大学
Wang Yan'en, Wang Yuebo, Yang Mingming, Pan Feilong, Li Xinpei, Wei Shengmin. Effectively Applying Database and Fractals to Bionic Design of Artificial Bone Scaffold[J]. Northwestern polytechnical university

基于知识库的骨支架可控分形设计
汪焰恩, 王月波, 杨明明, 潘飞龙, 李欣培, 魏生民
西北工业大学 机电学院, 陕西 西安 710072
摘要:
骨支架微观结构知识表达的欠缺,制约了可靠的人工骨支架仿生设计的科学依据和准则,间接影响骨支架仿生制造的研究和进展。基于Hausdorff分形几何理论,按照分形维数建立骨骼微孔形态分形维数知识规则,并根据分`形维数与孔隙率关系模型建立了二维平面骨支架孔隙率知识规则。系统地建立了从骨骼微观形态到人体骨微孔支架仿生设计的知识库设计方法。在分形维数与孔隙率双耦合因素作用下系统分析了孔隙率、孔填充数量与孔分形维数之间的关系,并分析和研究了微孔的分形维数和数量对填充之后的二维结构图的分形维数和孔隙率的影响。结果表明基于知识库的人工骨支架可控分形理论可以根据个体差异仿生设计骨支架微观结构特征,能够有效地为仿生制造提供驱动模型。
关键词:    人工骨支架    分形维数    微观结构    孔隙率   
Effectively Applying Database and Fractals to Bionic Design of Artificial Bone Scaffold
Wang Yan'en, Wang Yuebo, Yang Mingming, Pan Feilong, Li Xinpei, Wei Shengmin
Department of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China
Abstract:
The lack of knowledge representation for the microstructure of the bone scaffold restricts the reliable bionic design of artificial bone scaffold and restricts its guidelines methodology. Therefore,it limits the research and progress of bone scaffold bionic manufacturing. Based on the Hausdorff fractal geometry theory,we built the knowledge rule of bones microscopic pores shape fractal dimension according to the fractal dimension calculation results.And it established the knowledge rule of bone scaffold porosity in accordance with fractal dimension and with the porosity of the relational model. It systematically set up a bionic design methodology based on the relationship between bone micromorphology and human bone microscopic porous design. Doing suitable analyses,we demonstrated the relationship among the porosity,the number of filled pores,and the fractal dimension of the pattern of these pores. For individual differences in the microstructure of the bone scaffold properties,the calculated results show that,compared with other scaffold design methodology,our artificial bone scaffold bionic design based on controllable fractal theory and knowledge database is indeed effective.
Key words:    bone    calculations    design    fractal dimension    image analysis    image classification    knowledge management    microstructure    porosity    schematic diagrams    artificial bone scaffold    bionic design   
收稿日期: 2012-12-01     修回日期:
DOI:
基金项目: 国家自然科学基金(51175432、50905147);陕西省自然科学基金(2011JQ7005);中国博士后科学研究基金(200902606、2008044193);西北工业大学新人新方向(10GH0133);西北工业大学基础研究基金(JC20100230)资助
通讯作者:     Email:
作者简介: 汪焰恩(1976-),西北工业大学副教授、博士后,主要从事人工骨设计与快速成型、计算机辅助数值分析及制造业信息化的研究。
相关功能
PDF(1067KB) Free
打印本文
把本文推荐给朋友
作者相关文章
汪焰恩  在本刊中的所有文章
王月波  在本刊中的所有文章
杨明明  在本刊中的所有文章
潘飞龙  在本刊中的所有文章
李欣培  在本刊中的所有文章
魏生民  在本刊中的所有文章

参考文献:
[1] Geller J T, Holman H Y, Su G, et a1.Flow Dynamics and Potential for Biodegradation of Organic Contaminants in Fractured Rock Vadose Zones.Journal of Contaminant Hydrology, 2000, 43(1): 63-90
[2] Chen V J, Smith L A, Ma P X.Bone Regeneration on Computer-Designed Nano-Fibrous Scaffolds.Biomaterials, 2006, 27 (21): 3973-3979
[3] Xiong Zhuo, Yan Yongnian, Hu Yunyu, et al.Layered Manufacturing of Tissue Engineering Scaffolds via Multi-Nozzle Deposition.Progress in Rapid Prototyping and Rapid Manufacturing, 2002, 57(18): 2623-2628
[4] 汪焰恩, 魏生民等.人工骨支架多场耦合力学数值仿真.西北工业大学学报, 2009, 27(3): 362-367 Wang Yan'en, Wei Shengmin, et al.A Simulation Study of Artificial Bone Scaffold Based on Multi-Physics Coupling Model.Journal of Northwestern Polytechnical University, 2009, 27(3): 362-367 (in Chinese)
[5] 陈作炳, 饶 嵩, 李世普等.基于分形理论的人体骨微观结构仿生设计.武汉理工大学学报, 2004, 26(4): 49-51 Chen Zuobing, Rao Song, Li Shipu, et al.Bionic Design of Human Bone Microstructure Based on Fractal Theory.Journal of Wuhan Universtity of Technology, 2004, 26(4): 49-51 (in Chinese)
[6] Katz A J, Thompson A H.Fractal Sandstone Pores: Implications for Conductivity and Pore Formation.Phys.Rev.Lett.1984,54(12): 1325-1328
[7] 谢和平.分形与岩石力学.北京: 科学出版社, 1996 Xie Heping.Fractal Dimension—Introduction of Rock Mechanics.Beijing: Science Press, 1996 (in Chinese)
[8] 彭瑞东, 谢和平, 鞠 杨.二维数字图像分形维数的计算方法.中国矿业大学学报, 2004, 33(1): 19-24 Peng Ruidong, Xie Heping, Ju Yang.Computation Method of Fractal Dimensional for 2-D Digital Image.Journal of China University of Mining & Technology, 2004, 33(1): 19-24 (in Chinese)
[9] 汪焰恩, 闫秀天.基于分形理论的骨支架微观形态建模.西北工业大学学报, 2010, 28(4): 541-546 Wang Yanen, Yan Xiutian.Applying Fractal Methodology to Establishing Bone Scaffold Microstructure Models.Journal of Northwestern Polytechnical University, 2010, 28(4): 541 ~ 546 (in Chinese)
[10] 高国一, 杨 玲, 姜范波等.用 MetriscanTM 骨密度仪测量西双版纳、 西藏、 内蒙古地区健康人群骨密度的情况调查分析.中国骨质疏松杂志, 2008, 14(12): 875-879 Gao Guoyi, Yang Ling, Jiang Fangbo, et al.Investigation on Bone Mineral Density in Normal Group in Xishuangbanna, Tibet and Inner Mongolia.Chinese Journal of Osteoporosis, 2008, 14(12): 875-879 (in Chinese)
[11] 陈 超, 邢学农, 叶山东等.合肥地区 1162 例正常人群骨密度的分析研究.中国骨质疏松杂志, 2008, 14(6): 419-421 Chen Chao, Xing Xuenong, Ye Shandong, et al.A Study on Bone Mineral Density of 1162 Normal People in Hefei.Chinese Journal of Osteoporosis, 2008, 14(6): 419-421 (in Chinese)
[12] 徐建强, 胡蕴玉, 彦永年等.大段仿生活性人工骨修复兔长骨缺损的实验研究.中国创伤骨科杂志, 2005, 7 (9):840-843 Xu Jianqiang, Hu Yunyu, Yan Yongnian, et al.Experimental Research on Repairing Long Bone Defects of Rabbit with Large Segments of Simulated-Bioactive Bone Substitute.Chinese Journal of Orthopaedic Trauma, 2005, 7(9): 840-843 (in Chinese)
[13] Meyer U, Runte C, Dirksen D, et al.Image-Based Biomimetric Approach to Design and Fabrication of Tissue Engineered Bone.International Congress Series, 2003, 1256: 726-732
[14] 华锦明, 蔡丽君.骨组织工程支架及相关问题研究.中国骨肿瘤骨病, 2004, 3(2): 80-83 Hua Jinming, Cai Lijun.The Progress of Bone Tissue Engineering Scaffold and Relevant Research.Chinese Journal of Bone Tumor and Bone Disease, 2004, 3(2): 80-83